Purpose To describe the multicolour imaging (MI) findings in superficial and deep vascular plexus occlusions.In this retrospective observational study, patients diagnosed with central retinal artery and branch retinal artery occlusion, cotton-wool spot, paracentral acute middle maculopathy and acute macular neuroretinopathy between January 2018 and June 2019 were included. Colour fundus photograph, optical coherence tomography and MI of these patients were analysed.
A total of 41 eyes of 40 patients were included in this study. In eyes with central retinal artery occlusion, MI showed white areas in the retina with orange foveal centre. In eyes with branch retinal artery occlusion, MI showed white area along the affected retinal quadrant without an orange foveal centre. In pure superficial vascular plexus occlusions as in cotton-wool spots, the lesion was identified on MI as a white lesion. On MI, paracentral acute middle maculopathy showed parafoveal white areas with orange foveal centre while acute macular neuroretinopathy on MI parafoveal greyish-white areas with normal foveal centre.
En-face images using MI technology can provide yet another way to identify the level of retinal vasculature involvement which complements the existing gold standard of optical coherence tomography imaging.
En-face images using MI technology can provide yet another way to identify the level of retinal vasculature involvement which complements the existing gold standard of optical coherence tomography imaging.We aimed to evaluate the efficacy and safety of effective goniosynechialysis (GSL) under an endoscopic view combined with phacoemulsification in residual angle-closure glaucoma with lens opacity.
This was a retrospective study. Patients with residual angle-closure glaucoma, lens opacity, and uncontrolled intraocular pressure (IOP) who were receiving anti-glaucoma medications were selected to undergo effective GSL under an endoscopic view combined with phacoemulsification. Follow-up examinations were conducted until 6months postoperatively.
Twenty-five eyes of 24 patients diagnosed with residual angle-closure glaucoma and lens opacity and peripheral anterior synechiae (PAS) at least???270° were included. Their mean age was 61.32?±?6.11years. Preoperatively, the mean (standard error) IOP was 29.69 (11.22) mmHg, and the median number of IOP-lowering medications used was 3.0. The decreases in the rates of IOP of the patients were 44.29%, 52.17%, 46.95%, 48.37%, and 47.29% at 1day, 1week, 1month, 2.5months, and 6months after the surgery, respectively. https://www.selleckchem.com/ At 6months, the median number of IOP-lowering medications used decreased from 3 to 0 and the range of PAS compared to the baseline decreased from 312° to 107° (P?&lt;?0.001). We also found that 21/25 eyes achieved improved or stable visual acuity after surgery. Postoperative complications included transiently elevated IOP (12.0%), exudation (8.0%), and hyphema (4.0%).
Phacoemulsification combined with effective GSL under an endoscopic view may reopen residual angle-closure glaucoma and reduce the number of IOP-lowering medications for up to 6months. It is an effective and safe method for patients with residual angle-closure glaucoma and lens opacity.
Phacoemulsification combined with effective GSL under an endoscopic view may reopen residual angle-closure glaucoma and reduce the number of IOP-lowering medications for up to 6 months. It is an effective and safe method for patients with residual angle-closure glaucoma and lens opacity.The hemostimulating effects of c-Jun N-terminal kinase (JNK) inhibitor were examined on the mouse model of myelosuppression provoked by 5-fluorouracil. Blockade of JNK during postcytostatic period accelerated recovery of granulomonocytopoiesis and erythropoiesis. It also increased the content of neutrophilic granulocytes and erythroid cells in the hematopoietic tissue and elevated the counts of neutrophils and reticulocytes in the peripheral blood. The development of these phenomena resulted from elevated content and up-regulated functional activity of bone marrow hematopoietic progenitors associated with the direct action of JNK inhibitor on these progenitors and enhanced secretion of hemopoietins by stromal elements of the hematopoiesis-inducing microenvironment.We studied the effect of Semax on the state of intestinal microbiota in rats subjected to restraint stress. Semax was injected to Wistar male rats intraperitoneally in doses of 5, 50, 150, 450 μg/kg 12-15 min before modelling chronic restraint stress. It was found that stress exposure reduced the number of obligate bacteria in the colon microbiota, but increased the content of opportunistic microorganisms. Semax in doses of 50 and 150 μg/kg prevented the stress-induced changes in the composition of colon microbiota. The observed effects of Semax might be mediated by the central neurotropic effects as well as by binding to peripheral melanocortin receptors of the intestine.Endogenous neuropeptide cyclo-L-prolylglycine possesses mnemotropic and neuroprotective properties, which can result from its positive effect on the level of brain-derived neurotrophic factor and modulation of activity of insulin-like growth factor-1 and AMPA receptors. For detection of possible mitogenic action of cyclo-L-prolylglycine, we analyzed its effect on proliferative activity of HEK293 and SH-SY5Y cells assessed by expression of Ki-67 proliferation marker, cell cycle examination, and incorporation of modified nucleotide analog EdU into DNA. Cyclo-L-prolylglycine did not affect the level of Ki-67 in examined cell lines and distribution of the cells over G1 and G2 phases of the cell cycle, although it insignificantly reduced the percentage of S phase cells, which attested to the absence of intrinsic mitogenic activity of the peptide. At the same time, cyclo-L-prolylglycine reduced the number of the early apoptotic cells, which can be a mechanisms of its protective action.The possibility of development of dependence was studied during the intermittent consumption of sucrose, sodium chloride, and sodium glutamate solutions. Rats were allowed to choose and consume solutions of sucrose, sodium chloride, and sodium glutamate for 28 days. On days 29-31 of the experiment, the animals were deprived of the preferred solutions. On days 32-33, the solutions of sucrose, sodium chloride, and sodium glutamate, but not water were provided again. The consumption of sucrose and sodium chloride solutions did not increase, but consumption of 0.5 and 1% sodium glutamate solutions increased after 3-days withdrawal. The consumption of 2% solution of sodium glutamate was the same before and after withdrawal. The observed effects of sodium glutamate deprivation probably indicate the development of pathological glutamate dependence.